TIRI Supports the Preliminary Research for Biomedical Optics Sensor


Spider silk is a natural protein biopolymer with great elasticity, tensile strength, biodegradability, and biocompatibility. Due to its superior properties, spider silk has often been used in the fabrication of optical components in biomedical applications.

Comparing to other species, spider silk from Nephila pilipes has higher sensibility to chemical and magnetic materials. Noticing this characteristics, the joint research team from Professor Cheng-Yang Liu of National Yang Ming Chiao Tung University and Professor Chia-Hsiung Cheng of Taipei Medical University started this innovative research. With the team's request, TIRI assisted to customize sputtering system and co-instructed graduate students to design experiments and measurements

This study proposed a novel strategy using metal-nanolayer-coated spider silk-based optical fiber for real-time sugar concentration sensing, with high precision (CV= 0.862) and high accuracy (RMSE=0.51). With further development, it could lead to better at-home medical monitoring devices and point-of-care diagnostic and testing devices, useful for measuring blood sugar and other biochemical analytes in real-time.

This innovative joint research was published and selected as Editors' Pick in Biomedical Optics Express (BOEx), a principal journal in the optics and photonics community ( Related research results were reported by Nanowerk News: .

(Photo provided by Professor Cheng-Yang Liu from National Yang Ming Chiao Tung University)